Besides genetic triggers of those syndromes, In addition there are scenarios where the Snrpn/Ube3A cluster is intact but its genes are epigenetically misregulated. This is for instance the case if both of those homologs of chromosome 15 originate in the exact dad or mum, a situation named uniparental disomy (UPD). Maternal UPD is chargeable for PWS
In a little subset of mammalian genes, among the list of two inherited copies (alleles) is switched off. Which allele is matter to “genomic imprinting” is depending on regardless of whether it was inherited within the mother or The daddy. Genomic imprinting is a developmentally decided epigenetic method and leads to some “imprinted genes” o
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